The town is characterized by rolling terrain and rainfed rice fields. Nears thepoblacion, or town plaza, the road passes along the Mabini river, which drains into the South China Sea further west. The town plaza is home to a centuries old Roman Catholic church, as well as one of the first congregations of the Philippine Independent Church. The town shares borders with the town of Bani to the north, the town of Mabini and Alaminos City to the east and with Burgos to the south.

The town's main livelihood is fishing and agriculture, although a number of her sons and daughters work as doctors, nurses, engineers, computer programmers and accountants in numerous countries around the globe. During the summer months of April and May the town's market abounds with fresh fruits such as mangoes and duhat, as well as fresh catch such as tuna, flying fish, grouper, lobsters and other seafood.

The town is home to natural attractions such as the Mabini river, the Umbrella Rocks in Sabangan, as well as several beaches — Agno Beach being the longest and most popular. There are several other beaches hidden along the coast such as the Macaboboni cove (which features a small cave) as well as a white beach in Brgy. Gayusan. To the southern end of Agno Beach, one can dive from a two story high rock amidst crashing waves and end up in a beautiful coral garden below.

Arthur Cabantac was the mayor of Agno from 2007 until he was shot while playing Mahjong.

Agno is politically subdivided into 17 barangays.